10 Best Longevity and Anti-Ageing Supplements

What is Longevity?

Longevity refers to the length of an individual's life, particularly the extension of a healthy life well beyond the average lifespan within a population. It includes wanting to live longer and stay healthy, without chronic diseases or disabilities that come with getting older.

What is Healthspan?

Healthspan is the time in a person's life when they are healthy and free from chronic diseases and significant disabilities. Healthspan is about the quality of years lived, not just the total years. It's essential to take care of physical, mental, and emotional well-being as we get older, not just focus on lifespan.

Potential Benefits of Resveratrol

• Heart Health: Resveratrol is believed to support cardiovascular health, as a 2020 study found that through various mechanisms, including improving endothelial function, reducing inflammation, and offering protection against the oxidation of LDL cholesterol, which is a crucial factor in the development of atherosclerosis.
• Ageing and Longevity: Studies suggest that resveratrol can activate specific genes associated with longer lifespans and mimic the effects of caloric restriction, a known factor in extending lifespan in various organisms. Furthermore, findings conclude that It may influence mechanisms involved in ageing, such as DNA repair, the production of protective enzymes, and the reduction of inflammatory processes.
• Metabolic Benefits: There is evidence to suggest that resveratrol can improve insulin sensitivity and help manage blood glucose levels, according to a 2018 study, making it a compound of interest in the context of metabolic syndrome and diabetes prevention.
• Neuroprotection: Preliminary research indicates that resveratrol may have protective effects on brain health, potentially reducing the risk of neurodegenerative diseases like Alzheimer's by inhibiting the buildup of plaques and oxidative stress in the brain.

2. NAD+ Boosters (NMN: Nicotinamide mononucleotide)

Nicotinamide Mononucleotide (NMN) is a critical precursor to Nicotinamide Adenine Dinucleotide (NAD+), a coenzyme essential for a wide array of biological processes. NAD+ plays a pivotal role in energy metabolism, DNA repair, and the regulation of cellular and ageing processes, making NMN supplementation a promising avenue for enhancing longevity and healthspan.

Sources of NMN

 NMN is present in small quantities in foods such as avocados, broccoli, cabbage, cucumbers, and edamame. However, these amounts are not sufficient to impact the levels of NAD+ in other nutrients in the body. This led to NMN supplements being created to increase NAD+ levels in other nutrients more effectively than diet alone.

How Much to Take Daily

The optimal dosage of NMN is still under investigation, with human studies still exploring a wide range of doses. Most human studies have used doses ranging from 250 mg to 1,000 mg per day, showing promising results in terms of safety and efficacy. However, individual needs may vary, and it's advisable to consult with a healthcare provider to determine the appropriate dosage.

3. Spermidine: A Key to Cellular Renewal and Longevity

Spermidine is a naturally occurring compound found both in the body and various foods. It plays a crucial role in autophagy, the body's cell renewal and cleaning process, which is linked to increased lifespan.

• Sources: You can find spermidine in foods like wheat germ, aged cheese, mushrooms, and soy products. It's also available as a dietary supplement for those looking to boost their intake.
• Benefits: By promoting autophagy, spermidine helps in the maintenance of cellular health, potentially extending longevity and enhancing overall well-being.
• Dosage: While there's no established guideline for supplement dosage, incorporating spermidine-rich foods into your diet is a safe way to enjoy its benefits.

4. Pterostilbene: Nature's Antioxidant Powerhouse

Pterostilbene, a natural compound akin to resveratrol, is celebrated for its potent antioxidant effects. Found in the heart of blueberries and grapes, this compound offers a myriad of health benefits.

• Sources: Richly present in blueberries and grapes, pterostilbene is also available as a dietary supplement, making it easy to incorporate into your daily routine.
• Health Benefits: According to recent studies, pterostilbene shines in its ability to bolster heart health and cognitive function while playing a significant role in anti-ageing efforts. Its antioxidant properties help combat oxidative stress, contributing to overall well-being.
• Recommended Dosage: For those considering supplementation, initial studies recommend a daily intake of 50-250 mg. This range is suggested to harness pterostilbene's full potential while ensuring safety and efficacy.

5. Probiotics

Probiotics are live microorganisms, encompassing both bacteria and yeasts, that confer numerous health benefits, particularly to the digestive system.

• Natural Sources: These beneficial microbes are abundant in fermented foods such as yoghurt, kefir, and sauerkraut, as well as available in supplement form.
• Health Perks: Regular consumption of probiotics is linked to gut health and potential longevity benefits, along with a positive influence on mental wellbeing.
• Recommended Dosage: The appropriate intake of probiotics can significantly vary based on the specific strain. It's essential to refer to product labels for guidance and consult with healthcare professionals for personalised advice.

Discover the power of our brand new Digest Capsules at Naturecan today – A unique blend of inulin, live bacterias including LactoSpore®, vitamins and Chloride which contributes to normal digestion by the production of hydrochloric acid in the stomach (1), along with Vitamin C and Vitamin D3 to support the normal functioning of the immune system (2).

6. Rosmarinus (Rosmarinic acid)

Rosmarinus officinalis, commonly known as rosemary, is a herb known for its aromatic and therapeutic properties. One of its active compounds, rosmarinic acid, has been studied for various health benefits, including its potential impact on longevity and healthspan. Here's how rosmarinic acid might influence these areas:

• Antioxidant Properties: According to studies, rosmarinic acid is a potent antioxidant that helps neutralise harmful free radicals in the body. By reducing oxidative stress, it may help protect cells from damage that contributes to ageing and the development of chronic diseases.
• Anti-inflammatory Effects: A 2022 review found that chronic inflammation is associated with many age-related diseases. Rosmarinic acid has been shown to have anti-inflammatory properties, which could potentially reduce the risk of conditions like heart disease, diabetes, and Alzheimer's, thereby potentially contributing to a longer healthspan.
• Neuroprotective Effects: There is evidence to suggest that rosmarinic acid has neuroprotective effects, which could play a role in preventing or slowing the progression of neurodegenerative diseases such as Alzheimer's and Parkinson's. This could contribute to maintaining cognitive function and quality of life in older age.
• Supporting Metabolic Health: Some studies suggest that rosmarinic acid may have beneficial effects on metabolic health, including improving insulin sensitivity and reducing the risk of obesity and type 2 diabetes. Metabolic health is crucial for longevity and a healthy ageing process.

7. Sirtuin 6 (SIRT6): Enhancing Cellular Health

SIRT6 belongs to the sirtuin family, proteins crucial for DNA repair, metabolism regulation, and ageing. It deacetylates proteins, an essential process for cellular health and longevity.

Sources:

Endogenously produced, SIRT6 activity can be boosted by lifestyle choices. Caloric restriction, physical exercise, and a diet rich in polyphenols (from berries, nuts, and red wine) enhance its function.

Potential Benefits:

• Longevity: This plays a vital role in DNA repair and telomere maintenance, contributing to cell longevity.
• Metabolic Health: Helps regulate glucose and lipid metabolism, aiding in metabolic disease prevention.
• Inflammation Reduction: Involved in suppressing inflammatory responses, potentially reducing related diseases.

The Role of Lifestyle and Genetics

Longevity is influenced by a combination of genetics and lifestyle choices. While genetic factors can predispose individuals to longer lives, lifestyle choices are crucial. Healthy diets, regular physical activity, stress reduction, and avoidance of harmful habits like smoking and excessive alcohol consumption can significantly contribute to extending one's lifespan and improving overall health quality.

The Impact of Modern Medicine and Technology

Advancements in medical science and technology have also played a pivotal role in reducing mortality and extending average life expectancies. Innovations in healthcare, from vaccines and antibiotics to modern surgical techniques and chronic disease management, have drastically reduced mortality rates from infectious diseases and improved outcomes for various health conditions.

Longevity and Quality of Life

Ultimately, the pursuit of healthy longevity supports healthy ageing, and is not just about adding more years to life but adding more life to those years. It involves enhancing the quality of life, maintaining physical and mental health, and ensuring that individuals can live independently and with dignity as they age.

1. Omega-3 Fatty Acids: Essential for Heart and Brain Health

Omega-3 fatty acids are vital nutrients known for their anti-inflammatory effects, crucial in supporting brain function and cardiovascular health.

• Natural Sources: Available in fatty fish, flaxseeds, chia seeds, and as dietary supplements.
• Health Benefits: Promotes heart health, cognitive function, and reduces inflammation.
• Recommended Dosage: 250-500 mg of EPA and DHA daily.
• Naturecan offers both fish oil-based and vegan omega-3 supplements, catering to diverse dietary preferences.

2. Vitamin D: The Sunshine Vitamin for Immune Support

Vital for bone health, immune function, and reducing inflammation, Vitamin D is synthesised when the skin is exposed to sunlight.

• Sources: Sunlight, fatty fish, fortified foods, and supplements.
• Benefits: Enhances bone and immune health, and may lower the risk of chronic diseases.
• Dosage: 600-800 IU daily for adults, with adjustments for specific needs.

3. Collagen Supplements: Foundation of Youthful Vitality

Collagen, a key protein, supports skin, bones, and other nutrients in connective tissues, aiding in maintaining their strength and elasticity.

• Natural Sources: Produced by the body, with bone broth and animal proteins as dietary sources. Collagen supplements offer a direct boost.
• Health Benefits: Improves skin hydration, joint health, and bone density.
• Recommended Dosage: 5-15 grams of collagen peptides daily for optimal benefits.

4. Curcumin: Turmeric's Anti-Inflammatory Gem

Curcumin, the active compound in turmeric, boasts powerful anti-inflammatory and antioxidant properties.

• Source: Extracted from turmeric spice.
• Health Advantages: Reduces inflammation, boosts cognitive function, and may lower disease risk.
• Optimal Intake: 500-2000 mg of turmeric extract daily, standardised for high curcumin content.

Naturecan's Active Curcumin formula is designed to maximise these benefits.

5. Coenzyme Q10 (Q10) Capsules: Energising Antioxidant

CoQ10 is essential for energy production and acts as an antioxidant, supporting heart health and cellular vitality.

• Diverse Sources: Found in meats, fish, nuts, and as a supplement.
• Health Advantages: Enhances heart health, reduces headaches, and boosts energy levels.
• Optimal Dosage: 100-200 mg daily to leverage CoQ10's health-promoting effects.

6. Green Tea Extract: Antioxidant Powerhouse

A potent concentrate derived from green tea leaves, green tea extract is abundant in antioxidants, particularly catechins, known for their health-promoting properties.

• Natural Sources: Extracted directly from the leaves of green tea, ensuring a high concentration of its beneficial compounds.
• Health Benefits: Regular intake is linked to potential weight loss, enhanced cognitive performance, and a lowered risk of cancer.
• Recommended Dosage: For optimal results, a daily dosage of 250-500 mg, standardised for its catechin content, is advised.

7. Astaxanthin: Nature's Super Antioxidant

Astaxanthin stands out as a keto-carotenoid, celebrated for its exceptional antioxidant properties that combat oxidative stress and cellular damage.

• Primary Sources: This powerful compound is naturally found in marine sources such as salmon and trout, certain species of algae, and is also available in concentrated supplement form.
• Key Benefits: Its consumption is associated with numerous health advantages, including the promotion of skin vitality, reduction of inflammatory responses, and bolstering of eye health.
• Suggested Dosage: Research supports a daily intake ranging from 4 to 12 mg to harness astaxanthin's full spectrum of health benefits effectively.

8. Vitamin B Complex: For alertness and energy

The vitamin B complex includes eight B vitamins that play a vital role in energy production, brain and immune function, and cell metabolism.

• Sources: Whole grains, meat, eggs, dairy products, legumes, seeds, nuts, and supplements.
• Benefits: Supports energy levels, brain health, and cellular metabolism.
• Dosage: Varies by specific B vitamin; it's generally recommended to follow RDA guidelines or consult a healthcare provider.

9. Biotin: Essential for Radiance and Vitality

Biotin, also known as Vitamin B7, plays a pivotal role in maintaining radiant hair, supple skin, and strong nails. Beyond its beauty benefits, it's crucial for optimising energy metabolism.

• Natural Sources: Incorporate biotin-rich foods into your diet for a natural boost. Excellent sources include eggs, a variety of nuts and seeds, and liver, ensuring a balanced intake.
• Key Benefits: Biotin could excel in energising the body's metabolism while nurturing the health of your hair, skin, and nails, promoting an overall glow and vitality.
• Recommended Dosage: For adults, a daily intake of 30 micrograms (mcg) is recommended to meet your nutritional needs and support bodily functions effectively.